Geanncarlo Lugo-Villarino, PhD
Decoding Lung Tissue Niches in Tuberculosis
Cellular & Molecular Immunologist | IPBS-CNRS, Toulouse, France
Decoding Lung Tissue Niches in Tuberculosis
Cellular & Molecular Immunologist | IPBS-CNRS, Toulouse, France
"Welcome to my research site, where we explore how tissue microenvironments shape immune responses in tuberculosis (TB) and related conditions to uncover new pathways for therapeutic innovation."
Spatial organization of lung macrophage subsets.Immunofluorescence image of murine lung showing nerve-associated macrophages (NAMs) aligned with β3-tubulin⁺ neural structures (TUBB3, red), alveolar macrophages (AMs) within alveolar spaces (SIGLEC-F, blue), and SIGLEC-1⁺ macrophages (green) distributed across interstitial and pleural niches. @Arnaud Metais & Sarah Monard
My research program investigates how Mycobacterium tuberculosis remodels the lung tissue landscape by reshaping neuro-immune and perivascular niches. Within the broader TB research framework at IPBS, I lead an independent axis dedicated to defining how stromal compartments instruct macrophage specialization and determine infection outcomes. Our work aims to shift TB research from cell-centered immunity toward tissue-level regulatory architecture.