Research Axis

Perivascular Niche

Spatial Transcriptomic  Image @GCLugo

Rationale: Macrophages at the endothelial-stromal interface regulate vascular permeability and immune cell entry.  Multi-omics support a protective role of the mural cell-macrophage interaction against fibrotic evolution.

Neuro-Immune Niche

IF Image @Arnaud Metail & Sarah Monard

Rationale: Lung innervation massively increases around the peribronchial regions during infection. The cellular and molecular mechanisms responsible for this phenomenon in the context of tuberculosis remain unexplored. 

Peribronchial/alveolar Niche 

@Iakobachvili N et al. Molecular Microbiology (2021)

Rationale: The alveolar niche is the primary site of M. tuberculosis infection, where tissue signals shape macrophage metabolism and function. We use human organoids and multi-organ-on-chip systems to model these interactions.